aflibercept   Click here for help

GtoPdb Ligand ID: 6786

Synonyms: AVE0005 | Eylea® | VEGF Trap | Zaltrap® | ziv-aflibercept
Approved drug
aflibercept is an approved drug (FDA (2011), EMA (2012))
Compound class: Peptide
Comment: Alfibercept is a fusion protein combining the Fc portion of human IgG with the ligand binding domains of the VEGRF1 and VEGRF2 receptors.

Biosimilars:
Patent protection for originator alfibercept was expected to expire earliest in Japan and China (2022), then in US (2023, if Regeneron's extended patent claims were accepted) and the EU (2025), and biosimilar development proceeded during the run-up to patent expiry [4]. Early examples included Momenta Pharmaceuticals/Mylan's M710MYL-1701P, Alteogen's ALT-L9 (a heat stabilised formulation with a predicted longer shelf-life than Eylea; NCT04058535), and Formycon/Santo Holdings' FYB203.

The table below lists Eylea biosimilars with regulatory approval.

NameTrade nameCompanyClinical PhaseIndications
aflibercept-jbvfYesafili®Biocon BiologicsUK MHRA & EMA (2023), FDA (2024)As per originator reference product; interchangeable
aflibercept-yszy (SB15)Opuviz®BiogenFDA (2024)As per originator reference product; interchangeable
aflibercept-mrbb (FYB203)Ahzantive®Formycon/Klinge BiopharmaFDA (2024), EMA (2025)As per originator reference product
aflibercept-abzv (SOK583A1)Enzeevu®SandozFDA (2024)As per originator reference product
aflibercept-ayyh (ABP 938) [3]Pavblu ®AmgenFDA (2024)As per originator reference product
Classification Click here for help
Compound class Peptide
Approved drug? Yes. FDA (2011)  |  EMA (2012)
International Nonproprietary Names Click here for help
INN number INN
8739 aflibercept
Synonyms Click here for help
AVE0005 | Eylea® | VEGF Trap | Zaltrap® | ziv-aflibercept
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 214
Reactome Drug Reactome logo R-ALL-9679475
Reactome Reaction Reactome logo R-HSA-9679477
Other databases
CAS Registry No. 862111-32-8
ChEMBL Ligand CHEMBL1742982
DrugBank Ligand DB08885
GtoPdb PubChem SID 178103392
PubChem SID 135347926
Search PubMed clinical trials aflibercept
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Wikipedia Aflibercept