α-latrotoxin   Click here for help

GtoPdb Ligand ID: 5897

Abbreviated name: alpha-LTX
Synonyms: alpha-latrotoxin | alpha-latrotoxin-Lt1a | alpha-LTX-Lt1a
Compound class: Peptide
Comment: From the venom gland of the black widow spider (Latrodectus mactans tredecimguttatus). α-latrotoxin has been reported to bind to several human proteins that are likely to contribute to its toxicity [1-4]. It induces massive release of neurotransmitters from vertebrate nerve terminals and endocrine cells.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Peptide
Synonyms Click here for help
alpha-latrotoxin | alpha-latrotoxin-Lt1a | alpha-LTX-Lt1a
Database Links Click here for help
Specialist databases
GPCRdb Ligand alpha-latrotoxin
Other databases
GtoPdb PubChem SID 178102520
UniProtKB P23631 (Lt)
Wikipedia Alpha-Latrotoxin