Li+   Click here for help

GtoPdb Ligand ID: 5212

Synonyms: lithium ion
Approved drug
Li+ is an approved drug (FDA (1970))
Compound class: Inorganic
Comment: Lithium is a long-standing psychiatric medicine of unclear mechanism. A number of enzymes have been proposed as potential targets of lithium action, including inositol monophosphatase, a family of structurally related phosphomonoesterases, and the protein kinase glycogen synthase kinase-3 (see [4] and the DrugBank link). Administered as salt formulations such as the carbonate PubChem CID 11125
Click here for help

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

✖

View interactive charts of activity data across species

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: lithium

Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
IMPase 1 Primary target of this compound Hs Inhibitor Inhibition 3.5 pKi - 2
⤷ pKi 3.5 [2]
glycogen synthase kinase 3 beta Hs Inhibitor Inhibition 2.6 pIC50 - 6
⤷ pIC50 2.6 (IC50 2.5x10-3 M) Competive with Mg2+ [6]
Ligand mentioned in the following text fields
Inositol monophosphatase overview
Glycine transporter subfamily comments
Inositol monophosphatase comments