HS-142-1

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Ligands
HS-142-1

GtoPdb Ligand ID: 4952

Synonyms: HS142-1

Comment: HS-142-1, a novel nonpeptide (polysaccharide) atrial natriuretic peptide (ANP) antagonist which specifically inhibits natriuretic peptide-induced vasorelaxation through the blockade of guanylyl cyclase-linked natriuretic peptide receptors [1]. It was purified from the fermentation broth of Aureobasidium pullulans var. melanigenum [3]. The compound consists of glucose and caproyl subunits. Hexaosyl fragment O-(3-O-caproyl-beta-D-glucopyranosyl)-(1-->6)-[O-(beta-D- glucopyranosyl)-(1-->6)-O-(3-O-caproyl-beta-D-glucopyranosyl)-(1--> 6)]2-D-glucopyranose, is among the major components of the molecule and ithis has been used as the basis for synthesising synthetic analogues of the polysaccharide.

References
1. Imura R, Sano T, Goto J, Yamada K, Matsuda Y. (1992) Inhibition by HS-142-1, a novel nonpeptide atrial natriuretic peptide antagonist of microbial origin, of atrial natriuretic peptide-induced relaxation of isolated rabbit aorta through the blockade of guanylyl cyclase-linked receptors. Mol Pharmacol, 42 (6): 982-90. [PMID:1362244]
2. Morishita Y, Sano T, Ando K, Saitoh Y, Kase H, Yamada K, Matsuda Y. (1991) Microbial polysaccharide, HS-142-1, competitively and selectively inhibits ANP binding to its guanylyl cyclase-containing receptor. Biochem Biophys Res Commun, 176 (3): 949-57. [PMID:1674870]
3. Morishita Y, Takahashi M, Sano T, Kawamoto I, Ando K, Sano H, Saitoh Y, Kase H, Matsuda Y. (1991) Isolation and Purification of HS-142-1, a Novel Nonpeptide Antagonist for the Atrial Natriuretic Peptide Receptor, from Aureobasidium sp. Agric Biol Chem, 55 (12): 3017-3025.

References

1. Imura R, Sano T, Goto J, Yamada K, Matsuda Y. (1992)
Inhibition by HS-142-1, a novel nonpeptide atrial natriuretic peptide antagonist of microbial origin, of atrial natriuretic peptide-induced relaxation of isolated rabbit aorta through the blockade of guanylyl cyclase-linked receptors.
Mol Pharmacol, 42 (6): 982-90. [PMID:1362244]

2. Morishita Y, Sano T, Ando K, Saitoh Y, Kase H, Yamada K, Matsuda Y. (1991)
Microbial polysaccharide, HS-142-1, competitively and selectively inhibits ANP binding to its guanylyl cyclase-containing receptor.
Biochem Biophys Res Commun, 176 (3): 949-57. [PMID:1674870]

3. Morishita Y, Takahashi M, Sano T, Kawamoto I, Ando K, Sano H, Saitoh Y, Kase H, Matsuda Y. (1991)
Isolation and Purification of HS-142-1, a Novel Nonpeptide Antagonist for the Atrial Natriuretic Peptide Receptor, from Aureobasidium sp.
Agric Biol Chem, 55 (12): 3017-3025.