EPA   Click here for help

GtoPdb Ligand ID: 3362

Synonyms: C20:5n-3,6,9,12,15 | eicosapentaenoic acid | icosapentaenoic acid
PDB Ligand
Compound class: Metabolite
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 13
Topological polar surface area 37.3
Molecular weight 302.22
XLogP 8.02
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCC=CCC=CCC=CCC=CCC=CCCCC(=O)O
Isomeric SMILES CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O
InChI InChI=1S/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
InChI Key JAZBEHYOTPTENJ-JLNKQSITSA-N
Classification Click here for help
Compound class Metabolite
IUPAC Name Click here for help
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid
International Nonproprietary Names Click here for help
INN number INN
6328 icosapent
Synonyms Click here for help
C20:5n-3,6,9,12,15 | eicosapentaenoic acid | icosapentaenoic acid
Database Links Click here for help
Specialist databases
GPCRdb Ligand EPA
Other databases
CAS Registry No. 10417-94-4 (source: Scifinder)
ChEBI CHEBI:28364
ChEMBL Ligand CHEMBL460026
DrugBank Ligand DB00159
DrugCentral Ligand 3174
GtoPdb PubChem SID 178100387
LIPID MAPS LMFA01030759
PubChem CID 446284
RCSB PDB Ligand EPA
Search Google for chemical match using the InChIKey JAZBEHYOTPTENJ-JLNKQSITSA-N
Search Google for chemicals with the same backbone JAZBEHYOTPTENJ
Search PubMed clinical trials icosapent
Search PubMed titles icosapent
Search PubMed titles/abstracts icosapent
UniChem Compound Search for chemical match using the InChIKey JAZBEHYOTPTENJ-JLNKQSITSA-N
UniChem Connectivity Search for chemical match using the InChIKey JAZBEHYOTPTENJ-JLNKQSITSA-N
Wikipedia Eicosapentaenoic_acid

Product suppliers

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Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.

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Tocris
Eicosapentaenoic Acid (links to external site)
Cat. No. 5979