tolyacetyl-c[DCys-Apa-DTrp-Orn-Val-Cys]-His-amide   Click here for help

GtoPdb Ligand ID: 2166

Compound class: Peptide
Comment: This synthetic peptide is an analogue of the conserved cyclic hexapeptide portion of urotensin-II (amino acids 5-10 of the endogenous peptide). A histidine replaces the valine in the carboxy terminal position 11 of the natural ligand.
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Peptide Sequence Click here for help
CXWXVCH
Cys-Apa-Trp-Orn-Val-Cys-His
Chemical Modification
The amino terminal is tolacetylated and the carboxy terminal is amidated. Cys1 and Trp3 are D-amino acids, X2 is Apa (3-aminopropionic acid) and X4 is Orn (ornithine). The peptide is cyclic with a disulphide bond forming between the Cys residues.