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gamgertamig   Click here for help

GtoPdb Ligand ID: 14455

Synonyms: CM336 | OM-336 | OM336
Immunopharmacology Ligand
Compound class: Antibody
Comment: Gamgertamig (OM336, formerly CM336) is a dual BCMA (TNFRSF17)/CD3e monoclonal antibody of the T cell engager class. It is proposed to target the B cells that drive certain autoimmune diseases and B cell malignancies.
Peptide sequences for the heavy and light chains of both the CD3e and BCMA arms of gamgertamig are claimed in Keymed Biosciences' patent US20240002540A1 [1].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
B cell maturation antigen Monkey Antibody Binding 9.8 pKd - 1
⤷ pKd 9.8 (Kd 1.6x10-10 M) [1]
B cell maturation antigen Hs Antibody Binding 8.9 pKd - 1
⤷ pKd 8.9 (Kd 1.3x10-9 M) [1]
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CD3e Hs Antibody Binding 7.5 pKd - 1
⤷ pKd 7.5 (Kd 3.1x10-8 M) [1]
CD3e Monkey Antibody Binding 7.4 pKd - 1
⤷ pKd 7.4 (Kd 4.3x10-8 M) [1]