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firsekibart   Click here for help

GtoPdb Ligand ID: 14399

Synonyms: Jin Beixin® (China)
Approved drug
firsekibart is an approved drug
Compound class: Antibody
Comment: Firsekibart (previously genakumab) is an IgG4λ monoclonal antibody that targets interleukin-1β (IL-1β). It was developed for anti-inflammatory potential. Based on peptide sequence matches for the heavy and light variable regions of firsekibart, this appears to be antibody 048Ab-4 (H2L6) in patent CN106928354A [2].
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-1β Hs Antibody Binding 8.8 pKd - 2
⤷ pKd 8.8 (Kd 1.48x10-9 M) [2]