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picankibart   Click here for help

GtoPdb Ligand ID: 14398

Synonyms: IBI 112 | IBI-112 | IBI112 | Pecondle® (China)
Approved drug
picankibart is an approved drug
Compound class: Antibody
Comment: Picankibart (IBI112) is a humanized monoclonal antibody that targets human IL-23A p19 subunit, for anti-inflammatory potential [1]. The antibody neutralises IL-23-mediated receptor signalling and blocks downstream signal transducer and activator of transcription 3 (STAT3) phosphorylation and IL-17 production.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-23A Hs Antibody Binding 11.3 pKd - 1
⤷ pKd 11.3 (Kd 4.8x10-12 M) [1]
Description: Binding affinity for recombinant hIL-23 determined by SPR
IL-23A Hs Antibody Binding 8.9 pIC50 - 1
⤷ pIC50 8.9 (IC50 1.25x10-9 M) [1]
Description: Measuring inhibition of hIL-23 binding to the hIL-23 receptor