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bocunebart   Click here for help

GtoPdb Ligand ID: 14313

Synonyms: ALD-1910 | ALD1910 | LU AG-09222 | Lu AG09222 | Lu-AG09222 | LuAG09222
Compound class: Antibody
Comment: Bocunebart (Lu AG09222 from Lundbeck; formerly ALD1910) is a humanized monoclonal antibody that targets both isoforms of PACAP (PACAP-27 and PACAP-38) [1-2]. It is designed to disrupt PACAP signaling via its receptors as a mechanism to reduce migraine episodes [2-3]. The PACAP epitope engaged by Lu AG09222 is nonlinear, with interactions at amino acids in positions 19, 22, 23, and/or 27 required for potent binding.
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Summary of Clinical Use Click here for help
Lu AG09222 was progressed to clinical evaluation to determine safety and efficacy as an anti-migraine therapy.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT04976309 A Single Dose Study of Lu AG09222 in a Headache Model With Healthy Subjects Phase 1 Interventional H. Lundbeck A/S 3
NCT05133323 A Study With Lu AG09222 in Adults With Migraine Who Have Not Been Helped by Prior Preventive Treatments Phase 2 Interventional H. Lundbeck A/S
NCT06323928 A Dose-finding Trial With Lu-AG09222 in Adults With Migraine Who Have Not Been Helped by Prior Preventive Treatments Phase 2 Interventional H. Lundbeck A/S
NCT04197349 Safety, Tolerability and Pharmacokinetics of ALD1910 in Healthy Men and Woman Phase 1 Interventional H. Lundbeck A/S