pegcetacoplan   Click here for help

GtoPdb Ligand ID: 13826

Synonyms: APL-2 | Empaveli®
Approved drug Immunopharmacology Ligand
pegcetacoplan is an approved drug
Compound class: Peptide
Comment: Pegcetacoplan is a compstatin family complement factor C3 inhibitor [6]. It contains two identical 12 amino acid compstatin-derived cyclic peptides [Ac-Ile-Cys(1)-Val-(Me)Trp-Gln-Asp-Trp-Gly-Ala-His-Cys(1)-Thr-NH2] that are bridged by a 40 kDa PEG moiety at their amidated carboxy termini to improve circulating half-life [4-5].
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
complement C3 Hs Inhibitor Inhibition 7.9 pKd - 5
⤷ pKd 7.9 (Kd 1.2x10-8 M) [5]
Description: Affinity of the monomeric parental compstatin analog Cp05 from which pegcetacoplan is constructed