pegcetacoplan   Click here for help

GtoPdb Ligand ID: 13826

Synonyms: APL-2 | Empaveli®
Approved drug Immunopharmacology Ligand
pegcetacoplan is an approved drug
Compound class: Peptide
Comment: Pegcetacoplan is a compstatin family complement factor C3 inhibitor [6]. It contains two identical 12 amino acid compstatin-derived cyclic peptides [Ac-Ile-Cys(1)-Val-(Me)Trp-Gln-Asp-Trp-Gly-Ala-His-Cys(1)-Thr-NH2] that are bridged by a 40 kDa PEG moiety at their amidated carboxy termini to improve circulating half-life [4-5].
Classification Click here for help
Compound class Peptide
Approved drug? Yes. FDA (2021)  |  EMA (2021)
International Nonproprietary Names Click here for help
INN number INN
10743 pegcetacoplan
Synonyms Click here for help
APL-2 | Empaveli®
Database Links Click here for help
CAS Registry No. 2019171-69-6 (source: WHO INN record)
GtoPdb PubChem SID 507750459
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