Bioactivity Comments

Xeligekimab binds human and primate IL-17A with high affinity [2]. It does not bind to mouse IL-17A or other IL-17 family peptides.

Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference IL-17A Hs Antibody Binding 9.9 pKd - 2 ⤷ pKd 9.9 (Kd 1.39x10-10 M) [2] Description: Binding affinity determined by SPR IL-17A/IL-17F Hs Antibody Binding 8.6 pKd - 2 ⤷ pKd 8.6 (Kd 2.47x10-9 M) [2] Description: Binding affinity determined by SPR