xaluritamig   Click here for help

GtoPdb Ligand ID: 13718

Synonyms: AMG 509 | AMG-509 | AMG509
Compound class: Antibody
Comment: Xaluritamig (AMG 509) is a humanised bispecific monoclonal antibody that targets six transmembrane epithelial antigen of the prostate 1 (STEAP1; on prostate tumour cells) and CD3e (on T cells) [2]. It is a bispecific T cell engager (BiTE) class monoclonal, that was designed for therapeutic use against prostate cancer. Engaging these two surface molecules facilitates immune mediated killing of STEAP1-expressing cancer cells. Cryo-electron microscopy reveals that the anti-STEAP1 Fab domain of xaluritamig binds to a STEAP1 homotrimer.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Bioactivity Comments
AMG 509 induces potent (picomolar) T cell-dependent cytotoxicity in cells that express high levels of STEAP1, but not in cells without STEAP1 on their surface [2].
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
STEAP family member 1 Hs Antibody Binding 10.5 pKd - 2
⤷ pKd 10.5 (Kd 3.18x10-11 M) [2]
CD3e Hs Antibody Binding 8.6 pKd - 2
⤷ pKd 8.6 (Kd 2.76x10-9 M) [2]