disitamab vedotin   Click here for help

GtoPdb Ligand ID: 13716

Synonyms: Aidixi® | RC-48 | RC48-ADC
Approved drug
disitamab vedotin is an approved drug
Compound class: Antibody
Comment: Disitamab vedotin (RC48) is an anti-epidermal growth factor receptor 2 (ERBB2; HER2) antibody-drug conjugate (ADC) [4]. Its cytotoxic payload is the potent antimitotic agent monomethyl auristatin E (MMAE). Antibody binding blocks ERBB2 signalling and intracellular release of MMAE inhibits microtubule formation and induces apoptosis. The antibody may also mediate antibody-dependent cell-mediated cytotoxicity (ADCC).
Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
erb-b2 receptor tyrosine kinase 2 Primary target of this compound Hs Antibody Inhibition - - - 2
⤷ [2]