paridiprubart   Click here for help

GtoPdb Ligand ID: 13714

Synonyms: EB05 | NI 0101 | NI-0101
Immunopharmacology Ligand
Compound class: Antibody
Comment: Paridiprubart (NI-0101; EB05) is a fully human monoclonal antibody that targets toll-like receptor 4 (TLR4) [2]. TLR4-induced signalling is a major contributor to pathological inflammatory responses. Paridiprubart blocks TLR4 signalling by preventing receptor dimerisation, thus disrupting receptor activation by any TLR4 ligand.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Monnet E, Choy EH, McInnes I, Kobakhidze T, de Graaf K, Jacqmin P, Lapeyre G, de Min C. (2020)
Efficacy and safety of NI-0101, an anti-toll-like receptor 4 monoclonal antibody, in patients with rheumatoid arthritis after inadequate response to methotrexate: a phase II study.
Ann Rheum Dis, 79 (3): 316-323. [PMID:31892533]
2. Monnet E, Lapeyre G, Poelgeest EV, Jacqmin P, Graaf K, Reijers J, Moerland M, Burggraaf J, Min C. (2017)
Evidence of NI-0101 pharmacological activity, an anti-TLR4 antibody, in a randomized phase I dose escalation study in healthy volunteers receiving LPS.
Clin Pharmacol Ther, 101 (2): 200-208. [PMID:27706798]