paridiprubart 
GtoPdb Ligand ID: 13714
|
Synonyms: EB05 | NI 0101 | NI-0101
Compound class:
Antibody
Comment: Paridiprubart (NI-0101; EB05) is a fully human monoclonal antibody that targets toll-like receptor 4 (TLR4) [2]. TLR4-induced signalling is a major contributor to pathological inflammatory responses. Paridiprubart blocks TLR4 signalling by preventing receptor dimerisation, thus disrupting receptor activation by any TLR4 ligand.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| Immunopharmacology Comments |
| Paridiprubart blocks TLR4 pathway signalling, as a mechanism to reduce TLR4-induced pathological inflammatory responses. |
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License