latozinemab

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latozinemab

GtoPdb Ligand ID: 13685

Synonyms: AL-001 | AL001

Comment: Latozinemab (AL001) is an anti-sortilin 1 (SORT1) monoclonal antibody. It is proposed to elevate progranulin levels by inhibiting the SORT1-mediated degradation pathway for progranulin (PGRN). This mechanism is being investigated as a disease‐modifying therapy for patients with frontotemporal dementia caused by loss-of-function mutations in GRN.

Summary
Biological activity
Clinical data
References

References
1. Kurnellas M, Mitra A, Schwabe T, Paul R, Arrant AE, Roberson ED, Ward M, Yeh F, Long H, Rosenthal A. (2023) Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia. J Transl Med, 21 (1): 387. [PMID:37322482]

References

1. Kurnellas M, Mitra A, Schwabe T, Paul R, Arrant AE, Roberson ED, Ward M, Yeh F, Long H, Rosenthal A. (2023)
Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia.
J Transl Med, 21 (1): 387. [PMID:37322482]