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bentracimab   Click here for help

GtoPdb Ligand ID: 13675

Synonyms: MEDI2452 | PB2452
Compound class: Antibody
Comment: Bentracimab (formerly PB2452, MEDI2452) is a antibody-derived biologic (a Fab only construct) that is designed to bind and reverse the anti-platelet effects of the P2Y12 receptor antagonist ticagrelor [3-4].
No information available.
Summary of Clinical Use Click here for help
Bentracimab is an advanced clinical candidate, with evidence of efficacy as a ticagrelor reversal agent [1,3-4].
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT03928353 Study to Evaluate the Safety, Tolerability, PK and PD of PB2452 in Healthy Younger, Older and Elderly Subjects Phase 2 Interventional SFJ Pharmaceuticals, Inc.
NCT04122170 Phase 2B Study to Evaluate the Efficacy of Bentracimab (PB2452) in Reversal of Ticagrelor in Subjects Aged 50-80 Years Old Phase 2 Interventional SFJ Pharmaceuticals, Inc.
NCT04286438 Bentracimab in Ticagrelor-treated Patients With Uncontrolled Bleeding or Requiring Urgent Surgery or Invasive Procedure Phase 3 Interventional SFJ Pharmaceuticals, Inc.