bentracimab   Click here for help

GtoPdb Ligand ID: 13675

Synonyms: MEDI2452 | PB2452
Compound class: Antibody
Comment: Bentracimab (formerly PB2452, MEDI2452) is a antibody-derived biologic (a Fab only construct) that is designed to bind and reverse the anti-platelet effects of the P2Y12 receptor antagonist ticagrelor [3-4].
Bioactivity Comments
The binding affinity of bentracimab for ticagrelor is 100 times more potent than the ligand's affinity for its target P2Y12 [2].
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
ticagrelor Hs Antibody Antagonist 10.7 pKd - 2
⤷ pKd 10.7 (Kd 2x10-11 M) [2]