nebokitug 
GtoPdb Ligand ID: 13666
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Synonyms: CM-101 | CM101
Compound class:
Antibody
Comment: Nebokitug is the INN for an anti-C-C motif chemokine ligand 24 (CCL24) monoclonal antibody (proposed INN list 131, August 2024). It is likely clinical lead CM-101 (ChemomAb Ltd.). CCL24 is a soluble cytokine that is an important regulator of inflammation and fibrosis in human diseases such as primary sclerosing cholangitis (PSC) [1], systemic sclerosis, metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH). It promotes recruitment and activation of both immune cells and fibroblasts and this combined action induces over-production of extracellular matrix components that underlie fibrosis. Blocking CCL24-mediated signalling, via its receptor CCR3, with CM-101 has demonstrated therapeutic potential in preclinical PSC models [3-4].
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