ponsegromab

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Ligands
ponsegromab

GtoPdb Ligand ID: 13663

Synonyms: PF-06946860 | PF06946860

Compound class: Antibody

Comment: Ponsegromab (PF-06946860) is a humanized monoclonal antibody that binds and neutralises the action of the GDF-15 cytokine. It was designed to inhibit aberrant GDF-15/GDNF family receptor alpha like (GFRAL)-mediated dysregulation of appetite in human diseases, particularly in cancer patients.

References
1. Beaumont KC, Breen DM, Lambert MA, Chabot JR, Shchors K, Apgar JR. (2023) Anti-GDF15 antibodies, compositions and methods of use. Patent number: US11566066B2. Assignee: Pfizer Inc. Priority date: 15/08/2019. Publication date: 31/01/2023.
2. Breen DM, Kim H, Bennett D, Calle RA, Collins S, Esquejo RM, He T, Joaquim S, Joyce A, Lambert M et al.. (2020) GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates. Cell Metab, 32 (6): 938-950.e6. [PMID:33207247]
3. Groarke JD, Crawford J, Collins SM, Lubaczewski S, Roeland EJ, Naito T, Hendifar AE, Fallon M, Takayama K, Asmis T et al.. (2024) Ponsegromab for the Treatment of Cancer Cachexia. N Engl J Med, 391 (24): 2291-2303. [PMID:39282907]

References

1. Beaumont KC, Breen DM, Lambert MA, Chabot JR, Shchors K, Apgar JR. (2023)
Anti-GDF15 antibodies, compositions and methods of use.
Patent number: US11566066B2. Assignee: Pfizer Inc. Priority date: 15/08/2019. Publication date: 31/01/2023.

2. Breen DM, Kim H, Bennett D, Calle RA, Collins S, Esquejo RM, He T, Joaquim S, Joyce A, Lambert M et al.. (2020)
GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates.
Cell Metab, 32 (6): 938-950.e6. [PMID:33207247]

3. Groarke JD, Crawford J, Collins SM, Lubaczewski S, Roeland EJ, Naito T, Hendifar AE, Fallon M, Takayama K, Asmis T et al.. (2024)
Ponsegromab for the Treatment of Cancer Cachexia.
N Engl J Med, 391 (24): 2291-2303. [PMID:39282907]