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ponsegromab   Click here for help

GtoPdb Ligand ID: 13663

Synonyms: PF-06946860 | PF06946860
Compound class: Antibody
Comment: Ponsegromab (PF-06946860) is a humanized monoclonal antibody that binds and neutralises the action of the GDF-15 cytokine. It was designed to inhibit aberrant GDF-15/GDNF family receptor alpha like (GFRAL)-mediated dysregulation of appetite in human diseases, particularly in cancer patients.
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Summary of Clinical Use Click here for help
Ponsegromab (PF-06946860) is a clinical candidate for the potential treatment of cancer cachexia [3]. Development for heart failure was discontinued at phase 2.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT05492500 A Study of Ponsegromab in People With Heart Failure Phase 2 Interventional Pfizer
NCT05546476 Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15 Phase 2 Interventional Pfizer In this study ponsegromab promoted significant weight gain in patients with established cancer cachexia.