olezarsen   Click here for help

GtoPdb Ligand ID: 13658

Synonyms: AKCEA-APOCIII-LRX | IONIS-APOCIII-LRX | ISIS-678354 | ISIS-APOCIII-LRX | Tryngolza®
Approved drug
olezarsen is an approved drug (FDA (2024))
Compound class: Nucleic acid
Comment: Olezarsen is an antisense GalNAc3-conjugated oligonucleotide (ASO) that targets the messenger RNA for apolipoprotein C-III (APOC3) as a mechanism to treat dyslipidemias [1-3,5]. The nucleotide sequence is chemically modified to optimise in vivo stability and hepatic delivery. We have been unable to resolve a full SMILES or HELM notation for the entire ASO.
Nucleic Acid Sequence Click here for help
(3'-5')AGCUUd(CTTGTCCAGC)UUUAU