zanidatamab   Click here for help

GtoPdb Ligand ID: 13627

Synonyms: zanidatamab-hrii | Ziihera® | ZW-25 | ZW25
Approved drug
zanidatamab is an approved drug (DA (2024))
Compound class: Antibody
Comment: Zanidatamab (ZW25) is an anti-ERBB2 (HER2) monoclonal antibody [3]. It is biparatopic, meaning that it interacts with two independent extracellular epitopes on the ERBB2 receptor. Antibody binding induces ERBB2 internalisation, as well as CDC, ADCC and ADCP. The two epitopes are those bound by trastuzumab (ECD4) and pertuzumab (ECD2). Zanidatamab was designed to treat ERBB2 over-expressing advanced solid tumours, in particular types other than breast cancer [4].
Classification Click here for help
Compound class Antibody
Approved drug? Yes. FDA (2024)
International Nonproprietary Names Click here for help
INN number INN
10997 zanidatamab
Synonyms Click here for help
zanidatamab-hrii | Ziihera® | ZW-25 | ZW25
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 735
Other databases
GtoPdb PubChem SID 504705446
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