Apta-1

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Apta-1

GtoPdb Ligand ID: 13556

Comment: Apta-1 is a 90-mer RNA aptamer that is designed to bind to a conserved region of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) as a mechanism to disrupt infectivity [1]. It contains 2'-OH RNA purine nucleotides and 2'-fluoro pyrimidine nucleotides (marked as 'f' in the sequence provided here). Apta-1 is also reported to bind to the heparin-binding exosite II of thrombin, which drives significant inhibition of protease-activated receptor (PAR) signalling in platelets and antithrombotic sequelae.

Summary
Biological activity
References
Structure
Immunopharmacology
Malaria

Immunopharmacology Comments
Apta-1 has anti-inflammatory effects on systemic septic responses [2-3]. It was tested in rodent models of hepatitis virus and coronavirus infections. Apta-1 administration reduced infection-induced hemorrhagic lung damage and promoted systemic anti-inflammatory effects in both models [4].

Immunopharmacology Comments

Apta-1 has anti-inflammatory effects on systemic septic responses [2-3]. It was tested in rodent models of hepatitis virus and coronavirus infections. Apta-1 administration reduced infection-induced hemorrhagic lung damage and promoted systemic anti-inflammatory effects in both models [4].