palopegteriparatide   Click here for help

GtoPdb Ligand ID: 13484

Synonyms: mPEG-PTH (1-34) | TransCon PTH | Yorvipath®
Approved drug
palopegteriparatide is an approved drug (EMA (2023), FDA (2024))
Compound class: Peptide
Comment: Palopegteriparatide is a synthetic parathyroid hormone mimetic prodrug. Structurally it is an N-terminally PEGylated fragment of amino acids 1-34 of the mature human peptide (84 aa) [1]. Palopegteriparatide is inactive at the PTH receptor until the peptide-PEG linker is cleaved, releasing the active PTH(1-34) peptide.
Classification Click here for help
Compound class Peptide
Approved drug? Yes. FDA (2024)  |  EMA (2023)
International Nonproprietary Names Click here for help
INN number INN
11060 palopegteriparatide
Synonyms Click here for help
mPEG-PTH (1-34) | TransCon PTH | Yorvipath®
Database Links Click here for help
CAS Registry No. 2222514-07-8 (source: WHO INN record)
GtoPdb PubChem SID 500839894
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