palopegteriparatide   Click here for help

GtoPdb Ligand ID: 13484

Synonyms: mPEG-PTH (1-34) | TransCon PTH | Yorvipath®
Approved drug
palopegteriparatide is an approved drug (EMA (2023), FDA (2024))
Compound class: Peptide
Comment: Palopegteriparatide is a synthetic parathyroid hormone mimetic prodrug. Structurally it is an N-terminally PEGylated fragment of amino acids 1-34 of the mature human peptide (84 aa) [1]. Palopegteriparatide is inactive at the PTH receptor until the peptide-PEG linker is cleaved, releasing the active PTH(1-34) peptide.

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Other Similar Sequences Click here for help
PTH  {Sp: Human}
Targets
PTH1 receptor; PTH2 receptor
PTH  {Sp: Rat}
Targets
PTH1 receptor; PTH2 receptor
[125I][Nle8,21,Tyr34]PTH-(1-34)-NH2 (rat)
Targets
PTH1 receptor; PTH2 receptor
[Arg19]PTH-(1-34) (human)
Targets
PTH1 receptor
[His5,Arg19]PTH-(1-34) (human)
Targets
PTH1 receptor
[His5]PTH-(1-34) (human)
Targets
PTH1 receptor; PTH2 receptor
[Nle8,18,Tyr34]PTH-(1-34)-NH2 (bovine)
Targets
PTH1 receptor
[Nle8,18,Tyr34]PTH-(3-34)-NH2 (bovine)
Targets
PTH1 receptor
[Phe23]PTH-(1-34) (human)
Targets
PTH1 receptor; PTH2 receptor
[Tyr34]PTH-(1-34) (human)
Targets
PTH1 receptor
[Tyr34]PTH-(1-34)-NH2 (human)
Targets
PTH1 receptor
[Tyr34]PTH-(3-34)-NH2 (human)
Targets
PTH1 receptor
[D-Trp12,Tyr34]PTH-(7-34) (bovine)
Targets
PTH1 receptor; PTH2 receptor
[D-Trp12]PTH-(7-34) (bovine)
Targets
PTH2 receptor
PTH  {Sp: Mouse}
Targets
PTH1 receptor; PTH2 receptor
teriparatide
Targets
PTH1 receptor; PTH2 receptor
PTH-(1-34) (rat)
Targets
PTH1 receptor; PTH2 receptor
[Ala1,12,Aib3,Gln10,hArg11,Trp14,Arg19]PTH-(1-34)-NH2
Targets
PTH1 receptor
[Ala1,12,Aib3,Gln10,hArg11,Trp14,Arg19]PTH-(1-28)-NH2 (human)
Targets
PTH1 receptor
[Ala1,12,Aib3,Gln10,hArg11,Trp14,Arg19]PTH-(1-21)-NH2 (human)
Targets
PTH1 receptor
[Ala1,12,Aib3,Gln10,hArg11,Trp14]PTH-(1-14)-NH2
Targets
PTH1 receptor