palopegteriparatide

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palopegteriparatide

GtoPdb Ligand ID: 13484

Synonyms: mPEG-PTH (1-34) | TransCon PTH | Yorvipath®

palopegteriparatide is an approved drug (EMA (2023), FDA (2024))

Comment: Palopegteriparatide is a synthetic parathyroid hormone mimetic prodrug. Structurally it is an N-terminally PEGylated fragment of amino acids 1-34 of the mature human peptide (84 aa) [1]. Palopegteriparatide is inactive at the PTH receptor until the peptide-PEG linker is cleaved, releasing the active PTH(1-34) peptide.

Summary
Biological activity
Clinical data
References
Structure
Similar ligands

Bioactivity Comments
The released PTH(1-34) is equivalent to the approved drug teriparatide, so PTH1 receptor affinity/potency will be similar to that reported for teriparatide.

Bioactivity Comments

The released PTH(1-34) is equivalent to the approved drug teriparatide, so PTH1 receptor affinity/potency will be similar to that reported for teriparatide.