MD5   Click here for help

GtoPdb Ligand ID: 13458

Synonyms: compound B [PMID: 39028865]
Compound class: Peptide
Comment: MD5 is a selective peptidomimetic transmembrane serine protease 6 (TMPRSS6) inhibitor [1]. TMPRSS6 is an hepatically-expressed molecular target for iron-overload conditions for which hepcidin upregulation has established therapeutic benefit.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C1=CC=C(C=C1)CCC(=O)N[C@@H](CC2=CSC=N2)C(=O)N[C@@H](C3CCCCC3)C(=O)N[C@@H](CCCNC(=N)N)C(=O)C4=NC5=C(C=CC=C5)S4
Isomeric SMILES O=C(C1=NC2=C(C=CC=C2)S1)[C@H](CCCNC(N)=N)NC([C@H](C3CCCCC3)NC([C@H](CC4=CSC=N4)NC(CCC5=CC=CC=C5)=O)=O)=O
InChI InChI=1S/C36H44N8O4S2/c37-36(38)39-19-9-15-27(32(46)35-43-26-14-7-8-16-29(26)50-35)42-34(48)31(24-12-5-2-6-13-24)44-33(47)28(20-25-21-49-22-40-25)41-30(45)18-17-23-10-3-1-4-11-23/h1,3-4,7-8,10-11,14,16,21-22,24,27-28,31H,2,5-6,9,12-13,15,17-20H2,(H,41,45)(H,42,48)(H,44,47)(H4,37,38,39)/t27-,28-,31-/m0/s1
InChI Key JGROXKKMPXLGHO-QYDYLWNGSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Peptide Sequence Click here for help
(H)Phe-ThiazolylAla-Chg-Arg(Kbt)
Chemical Modification
Chg= cyclohexylglycine
Kbt= ketobenzothiazole (a serine trap)
Download 2D Structure Click here for help
Canonical SMILES Download
Isomeric SMILES Download
InChI standard identifier Download
InChI standard key Download

Molecular structure representations generated using Open Babel