dazodalibep

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Ligands
dazodalibep

GtoPdb Ligand ID: 13453

Synonyms: MEDI-4920 | MEDI4920 | VIB 4920 | VIB-4920 | VIB4920

Comment: Dazodalibep (VIB4920, formerly MEDI4920) is a fusion protein that is designed to bind to and neutralise the biological actions of the CD40 ligand (CD40L) [1-2]. Structurally dazodalibep contains two tandem human Tn3 tenascin C modules (that bind CD40L [3]) linked to human serum albumin. Previous studies have demonstrated that anti-CD40L antibodies can cause thromboembolic adverse events that arise through antibody Fc-mediated cross-linking between FcγRIIa and CD40L on platelets. The dazodalibep Fc negative fusion protein approach was initiated to mitigate these platelet-related safety issues.

Summary
Biological activity
Clinical data
References
Structure
Immunopharmacology

Immunopharmacology Comments
The CD40/CD40L axis is a target for the devlopment of therapeutics to inhibit the humoral immune response in autoimmune diseases.

Immunopharmacology Comments

The CD40/CD40L axis is a target for the devlopment of therapeutics to inhibit the humoral immune response in autoimmune diseases.