vixarelimab

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vixarelimab

GtoPdb Ligand ID: 13451

Synonyms: KPL-716 | KPL716

Comment: Vixarelimab (KPL-716) is an anti-oncostatin M (OSM) receptor β subunit monoclonal antibody [1]. It disrupts both interleukin-31 and OSM signalling at the interface between immune cells and connective tissue/stromal cells, by attenuating the MCP-1 response to OSM. The effects of vixarelimab are distinct to those of an anti-IL-31 receptor α monoclonal.

Summary
Biological activity
Clinical data
References
Immunopharmacology

References
1. Richards CD, Gandhi R, Botelho F, Ho L, Paolini JF. (2020) Oncostatin M Induction of Monocyte Chemoattractant Protein 1 is Inhibited by Anti-oncostatin M Receptor Beta Monoclonal Antibody KPL-716. Acta Derm Venereol, 100 (14): adv00197. [PMID:32374409]

References

1. Richards CD, Gandhi R, Botelho F, Ho L, Paolini JF. (2020)
Oncostatin M Induction of Monocyte Chemoattractant Protein 1 is Inhibited by Anti-oncostatin M Receptor Beta Monoclonal Antibody KPL-716.
Acta Derm Venereol, 100 (14): adv00197. [PMID:32374409]