vixarelimab

Home
Ligands
vixarelimab

GtoPdb Ligand ID: 13451

Synonyms: KPL-716 | KPL716

Comment: Vixarelimab (KPL-716) is an anti-oncostatin M (OSM) receptor β subunit monoclonal antibody [1]. It disrupts both interleukin-31 and OSM signalling at the interface between immune cells and connective tissue/stromal cells, by attenuating the MCP-1 response to OSM. The effects of vixarelimab are distinct to those of an anti-IL-31 receptor α monoclonal.

Summary
Biological activity
Clinical data
References
Immunopharmacology

Immunopharmacology Comments
Vixarelimab (KPL-716) inhibits OSM-mediated MCP-1/CCL2 production in vitro [1].

Immunopharmacology Comments

Vixarelimab (KPL-716) inhibits OSM-mediated MCP-1/CCL2 production in vitro [1].