vixarelimab   Click here for help

GtoPdb Ligand ID: 13451

Synonyms: KPL-716 | KPL716
Immunopharmacology Ligand
Compound class: Antibody
Comment: Vixarelimab (KPL-716) is an anti-oncostatin M (OSM) receptor β subunit monoclonal antibody [1]. It disrupts both interleukin-31 and OSM signalling at the interface between immune cells and connective tissue/stromal cells, by attenuating the MCP-1 response to OSM. The effects of vixarelimab are distinct to those of an anti-IL-31 receptor α monoclonal.
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Oncostatin M-specific receptor, β subunit Hs Antibody Binding - - - 1
⤷ [1]