briquilimab   Click here for help

GtoPdb Ligand ID: 13450

Synonyms: AMG-191 | AMG191 | JSP-191 | JSP191
Immunopharmacology Ligand
Compound class: Antibody
Comment: Briquilimab (JSP191) is a chimeric humanized monoclonal antibody that targets KIT proto-oncogene receptor tyrosine kinase.
References
1. Jung D, Long-Boyle JR, Pang WW, Gobburu JVS. (2024)
Pharmacokinetics of Briquilimab as a Conditioning Agent for Hematopoietic Stem Cell Transplantation in Patients With Severe Combined Immunodeficiency, Myelodysplastic Syndrome, or Acute Myeloid Leukemia.
Transplant Cell Ther, 30 (9): 923.e1-923.e9. [PMID:38972509]
2. Wedi B. (2023)
Inhibition of KIT for chronic urticaria: a status update on drugs in early clinical development.
Expert Opin Investig Drugs, 32 (11): 1043-1054. [PMID:37897679]