marstacimab   Click here for help

GtoPdb Ligand ID: 13403

Synonyms: Hympavzi® | marstacimab-hncq
Approved drug
marstacimab is an approved drug (EMA & FDA (2024))
Compound class: Antibody
Comment: Marstacimab (PF-06741086) is a monoclonal antibody that targets tissue factor pathway inhibitor (TFPI) [4]. The antibody blocks the inhibitory effect of TFPI on the FVIIa-TF complex interaction with coagulation factor Xa. This mechanism is proposed to increase coagulation activity of both the intrinsic and extrinsic coagulation pathways, for example in patients with severe haemophilia A or B.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
tissue factor pathway inhibitor Hs Antibody Binding - - - 4
⤷ [4]