linvoseltamab   Click here for help

GtoPdb Ligand ID: 13305

Synonyms: REGN-5458 | REGN5458
Compound class: Antibody
Comment: Linvoseltamab (REGN5458) is an investigational bispecific monoclonal antibody that targets B cell maturation antigen (BCMA) and CD3e [1]. It simultaneously engages BCMA on B cells and CD3e on CD4+ and CD8+ T cells to induce T cell-mediated killing of BCMA+ve myeloma cells.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. DiLillo DJ, Olson K, Mohrs K, Meagher TC, Bray K, Sineshchekova O, Startz T, Kuhnert J, Retter MW, Godin S et al.. (2021)
A BCMAxCD3 bispecific T cell-engaging antibody demonstrates robust antitumor efficacy similar to that of anti-BCMA CAR T cells.
Blood Adv, 5 (5): 1291-1304. [PMID:33651100]