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anti-FXII nanobody N4-38   Click here for help

GtoPdb Ligand ID: 13274

Immunopharmacology Ligand
Compound class: Antibody
Comment: N4-38 is an anti-FXII nanobody that is designed to block the activation of FXII to FXIIa as an anti-thrombotic mechanism [1].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Wang M, Xu P. (2021)
Anti-fxii nanobody or antigen binding fragment thereof and use thereof.
Patent number: WO2021253662A1. Assignee: Ningbo Kangshan Biotechnology Co., Ltd.. Priority date: 21/09/2020. Publication date: 23/12/2021.
2. Zhang Y, Chen Z, Guo J, Wan Q, Zhang Y, Li H, Rao H, Yang J, Xu P, Chen H et al.. (2024)
Factor XII and prekallikrein promote microvascular inflammation and psoriasis in mice.
Br J Pharmacol, 181 (19): 3760-3778. [PMID:38872396]