amyloid β1-16   Click here for help

GtoPdb Ligand ID: 13243

Synonyms: Aβ(1-16) | N-Aβ
Compound class: Peptide
Comment: This is a 16 amino acid N-terminal fragment of amyloid β (Aβ) that is found in human cerebrospinal fluid [3-4]. The C-terminal lysine is is rapidly removed by carboxypeptidase, so the 15-mer is more abundant than the 16-mer. It is proposed that this truncated form of Aβ can block the neuronal instability caused by oligomeric Aβ1-42 that is mediated via interactions with α7-containing nicotinic acetylcholine receptors (nAChR), and that this mechanism may offer potential against memory loss in Aβ-associated neurodegenarative disease.
References
1. Forest KH, Taketa R, Arora K, Todorovic C, Nichols RA. (2021)
The Neuroprotective Beta Amyloid Hexapeptide Core Reverses Deficits in Synaptic Plasticity in the 5xFAD APP/PS1 Mouse Model.
Front Mol Neurosci, 14: 576038. [PMID:33912008]
2. Lawrence JL, Tong M, Alfulaij N, Sherrin T, Contarino M, White MM, Bellinger FP, Todorovic C, Nichols RA. (2014)
Regulation of presynaptic Ca2+, synaptic plasticity and contextual fear conditioning by a N-terminal β-amyloid fragment.
J Neurosci, 34 (43): 14210-8. [PMID:25339735]
3. Portelius E, Price E, Brinkmalm G, Stiteler M, Olsson M, Persson R, Westman-Brinkmalm A, Zetterberg H, Simon AJ, Blennow K. (2011)
A novel pathway for amyloid precursor protein processing.
Neurobiol Aging, 32 (6): 1090-8. [PMID:19604603]
4. Portelius E, Tran AJ, Andreasson U, Persson R, Brinkmalm G, Zetterberg H, Blennow K, Westman-Brinkmalm A. (2007)
Characterization of amyloid beta peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass spectrometry.
J Proteome Res, 6 (11): 4433-9. [PMID:17927230]