ordesekimab   Click here for help

GtoPdb Ligand ID: 13046

Synonyms: AMG-714 | AMG714 | MAb146B7 | PRV-015
Immunopharmacology Ligand
Compound class: Antibody
Comment: Ordesekimab (AMG714, formerly PRV-015) is a fully human anti-IL-15 monoclonal antibody [1]. It binds to Il-15-IL-15Rα complexes on monocytes and disrupts interaction of the cytokine-bound receptor α subunit with the IL-2Rβ and common γ chains of the IL-15 receptor complex that is necessary for receptor activation and downstream signalling.
No information available.
Summary of Clinical Use Click here for help
Ordesekimab (AMG714) is under clinical investigation for efficacy in autoimmune conditions.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT02633020 Study to Evaluate the Efficacy and Safety of AMG 714 in Adult Patients With Type II Refractory Celiac Disease Phase 2 Interventional Amgen
NCT00433875 Phase 2 AMG 714 in Rheumatoid Arthritis Phase 2 Interventional Amgen
NCT04338581 Evaluation of AMG 714 for Vitiligo Phase 2 Interventional National Institute of Allergy and Infectious Diseases (NIAID)