hIMB1636-MMAE   Click here for help

GtoPdb Ligand ID: 12978

Compound class: Antibody
Comment: hIMB1636-MMAE is an anti-TROP2 antibody-drug conjugate [1]. It binds to TROP2 on cancer cells and induces their death by apoptosis, ADCC and bystander effects. The MMAE (monomethyl auristatin E; a.k.a. vedotin) conjugate is a widely used microtubule disrupting agent that is liberated once the ADC is internalised by target cells. The PubChem ID for MMAE is CID 11542188.
Click here for help

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

✖

View interactive charts of activity data across species
References
1. Sun LP, Bai WQ, Zhou DD, Wu XF, Zhang LW, Cui AL, Xie ZH, Gao RJ, Zhen YS, Li ZR et al.. (2023)
hIMB1636-MMAE, a Novel TROP2-Targeting Antibody-Drug Conjugate Exerting Potent Antitumor Efficacy in Pancreatic Cancer.
J Med Chem, 66 (21): 14700-14715. [PMID:37883180]