tarlatamab   Click here for help

GtoPdb Ligand ID: 12969

Synonyms: AMG 757 | AMG-757 | AMG757 | Imdelltra® | tarlatamab-dlle
Approved drug
tarlatamab is an approved drug (FDA (2024))
Compound class: Antibody
Comment: Tarlatamab (AMG 757) is a bispecific T cell engager (BiTE®) type anti-Delta-like ligand 3 (DLL3) monoclonal antibody [5-6]. It co-engages DLL3 on cancer cells and CD3E on T cells to promote T cell-mediated tumour lysis. The rationale for investigating DLL3 as a cancer drug target is reviewed in [3].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Antibody
Approved drug? Yes (FDA (2024))
International Nonproprietary Names Click here for help
INN number INN
11420 tarlatamab
Synonyms Click here for help
AMG 757 | AMG-757 | AMG757 | Imdelltra® | tarlatamab-dlle
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 1073
Other databases
GtoPdb PubChem SID 485206090
Search PubMed clinical trials tarlatamab
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