ABBV-3373   Click here for help

GtoPdb Ligand ID: 12917

Synonyms: ADC 122 [3]
Immunopharmacology Ligand
Compound class: Antibody
Comment: ABBV-3373 is a investigational antibody-drug conjugate (ADC) in which a novel glucocorticoid receptor modulator payload is linked to the anti-TNαF antibody adalimumab [3]. It was designed to modulate TNF-mediated inflammatory pathways by delivering the glucocorticoid directly into activated immune cells that express membrane-bound TNFα, as a treatment for immune-mediated diseases such as rheumatoid arthritis.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Buttgereit F, Aelion J, Rojkovich B, Zubrzycka-Sienkiewicz A, Chen S, Yang Y, Arikan D, D'Cunha R, Pang Y, Kupper H et al.. (2023)
Efficacy and Safety of ABBV-3373, a Novel Anti-Tumor Necrosis Factor Glucocorticoid Receptor Modulator Antibody-Drug Conjugate, in Adults with Moderate-to-Severe Rheumatoid Arthritis Despite Methotrexate Therapy: A Randomized, Double-Blind, Active-Controlled Proof-of-Concept Phase IIa Trial.
Arthritis Rheumatol, 75 (6): 879-889. [PMID:36512671]
2. D'Cunha R, Kupper H, Arikan D, Zhao W, Carter D, Blaes J, Ruzek M, Pang Y. (2024)
A first-in-human study of the novel immunology antibody-drug conjugate, ABBV-3373, in healthy participants.
Br J Clin Pharmacol, 90 (1): 189-199. [PMID:37596703]
3. Hobson AD, McPherson MJ, Hayes ME, Goess C, Li X, Zhou J, Wang Z, Yu Y, Yang J, Sun L et al.. (2022)
Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate.
J Med Chem, 65 (23): 15893-15934. [PMID:36394224]