odronextamab

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Ligands
odronextamab

GtoPdb Ligand ID: 12690

Synonyms: Ordspono® | REGN-1979 | REGN1979

odronextamab is an approved drug (EMA (2024))

Comment: Odronextamab (REGN1979) is a fully human CD3ε/CD20 bispecific IgG4-based antibody that redirects CD3⁺ cytotoxic T cells to selectively destroy CD20+ve malignant B cells [3]. Fc-mediated effector function has been minimised by modification of the IgG4 Fc domain.

Summary
Biological activity
Clinical data
References

Bioactivity Comments
Induces target-dependent lysis of CD20+ve lymphoma cells by human and cynomolgus T cells in vitro (EC₅₀ 15-84 pM), and demonstrates anti-tumour activity in in vivo B cell lymphoma models [3].

Bioactivity Comments

Induces target-dependent lysis of CD20+ve lymphoma cells by human and cynomolgus T cells in vitro (EC₅₀ 15-84 pM), and demonstrates anti-tumour activity in in vivo B cell lymphoma models [3].

Selectivity at other protein targets

Key to terms and symbols

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Target			Sp.	Type	Action	Value	Parameter	Concentration range (M)	Reference
CD20 (membrane-spanning 4-domains, subfamily A, member 1)			Hs	Antibody	Binding	-	-	-	3
⤷	[3]