inclacumab   Click here for help

GtoPdb Ligand ID: 12312

Synonyms: HuMab 002 [2] | LC1004-002 | RO-4905417 | RO4905417
Immunopharmacology Ligand
Compound class: Antibody
Comment: Inclacumab (formerly RO4905417) is an IgG4κ monoclonal antobody that targets selectin P (CD62; SELP) [2] that was initially designed for potential to promote anti-inflammatory and antithrombotic effects as a mechanism to reduce atherosclerosis. It blocks the interaction between selectin P and its primary ligand, P-selectin glycoprotein ligand-1 (PSGL-1). Inclacumab was later repositioned to reduce vaso-occlusive crises in patients with sickle cell disease.
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
9512 inclacumab
Synonyms Click here for help
HuMab 002 [2] | LC1004-002 | RO-4905417 | RO4905417
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 402
Other databases
GtoPdb PubChem SID 479821103
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