mosunetuzumab   Click here for help

GtoPdb Ligand ID: 12298

Synonyms: BTCT4465A | CD20-TDB [7] | Lunsumio® | mosunetuzumab-axgb | RG-7828 | RO7030816
Approved drug
mosunetuzumab is an approved drug (EMA & FDA (2022))
Compound class: Antibody
Comment: Mosunetuzumab (BTCT4465A) is an anti-CD20(MS4A1)/CD3e bispecific antibody [7] that was developed by Roche/Genentech to eliminate CD20+ve B cell malignancies by recruiting and activating effector T cells [1,4-5].
References
1. Budde LE, Assouline S, Sehn LH, Schuster SJ, Yoon SS, Yoon DH, Matasar MJ, Bosch F, Kim WS, Nastoupil LJ et al.. (2022)
Single-Agent Mosunetuzumab Shows Durable Complete Responses in Patients With Relapsed or Refractory B-Cell Lymphomas: Phase I Dose-Escalation Study.
J Clin Oncol, 40 (5): 481-491. [PMID:34914545]
2. Budde LE, Sehn LH, Matasar M, Schuster SJ, Assouline S, Giri P, Kuruvilla J, Canales M, Dietrich S, Fay K et al.. (2022)
Safety and efficacy of mosunetuzumab, a bispecific antibody, in patients with relapsed or refractory follicular lymphoma: a single-arm, multicentre, phase 2 study.
Lancet Oncol, 23 (8): 1055-1065. [PMID:35803286]
3. Buske C. (2022)
Mosunetuzumab, a bispecific antibody, in patients with relapsed or refractory follicular lymphoma.
Lancet Oncol, 23 (8): 967-969. [PMID:35803285]
4. Ferl GZ, Reyes A, Sun LL, Cheu M, Oldendorp A, Ramanujan S, Stefanich EG. (2018)
A Preclinical Population Pharmacokinetic Model for Anti-CD20/CD3 T-Cell-Dependent Bispecific Antibodies.
Clin Transl Sci, 11 (3): 296-304. [PMID:29351372]
5. Hosseini I, Gadkar K, Stefanich E, Li CC, Sun LL, Chu YW, Ramanujan S. (2020)
Mitigating the risk of cytokine release syndrome in a Phase I trial of CD20/CD3 bispecific antibody mosunetuzumab in NHL: impact of translational system modeling.
NPJ Syst Biol Appl, 6 (1): 28. [PMID:32859946]
6. Kang C. (2022)
Mosunetuzumab: First Approval.
Drugs, 82 (11): 1229-1234. [PMID:35947358]
7. Sun LL, Ellerman D, Mathieu M, Hristopoulos M, Chen X, Li Y, Yan X, Clark R, Reyes A, Stefanich E et al.. (2015)
Anti-CD20/CD3 T cell-dependent bispecific antibody for the treatment of B cell malignancies.
Sci Transl Med, 7 (287): 287ra70. [PMID:25972002]