ZWB67 
GtoPdb Ligand ID: 12229
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Compound class:
Antibody
Comment: ZWB67 is a bispecific monoclonal antibody that simultaneously targets the tumour antigen claudin 18.2 (CLDN18.2) and the CD3e molecule on effector T cells [1]. It uses the VH and VL domains from the anti-hCD3e from Amgen's CD3e/PSMA bispecific pasotuxizumab. Affinity for CD3e is low by design. ZWB67 is intended to induce an anti-tumour immune response against CLDN18.2+ve cancers [1]. ZWB67 has demonstrated in vivo efficacy in a mice bearing MC-38-hCLDN18.2 xenograft tumours.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
Classification  |
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| Compound class | Antibody |
| Database Links |
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| GtoPdb PubChem SID | 473153817 |
| PubChem CID | 121365142 |
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Sponsored products disclaimer
Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.
Links are provided in return for sponsorship, used to fund improvements to this database. The sponsorship account is managed and audited by the University of Edinburgh, a charitable body registered in Scotland, SC005336. If you are interested in sponsoring the database, please contact us.
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Sebetralstat (links to external site)
Cat. No. HY-132830 |
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