SI5α-b   Click here for help

GtoPdb Ligand ID: 11604

Compound class: Peptide
Comment: SI5α-b is a small (7 amino acids) peptide that binds to the receptor-binding domain (RBD; specifically residues Y453, Q498 and N501) of the SARS-CoV-2 spike protein and thereby blocks its interaction with angiotensin-converting enzyme 2 (ACE2) [1]. It exhibits antiviral activity in vitro, in an assay of Vero E6 cell infection by the pangolin coronavirus virus GX_P2V.
Bioactivity Comments
The ability of SI5α-b to inhibit RBD-ACE2 binding was determined in a competition ELISA, but no IC50 was generated [1]. The EC50 for antiviral activity in the Vero E6/GX_P2V coronavirus model was 1.52 μM.
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CoV Spike glycoprotein SARS-CoV-2 None Binding - - - 1
⤷ [1]