evorpacept   Click here for help

GtoPdb Ligand ID: 11592

Synonyms: ALX-148 | ALX148
Compound class: Peptide
Comment: Evorpacept (ALX148) is a dimeric CD47-binding fusion protein that contains two copies of a modified SIRPα D1 domain fused to an inactive human IgG1 Fc domain [1]. It blocks the CD47-SIRPα "don't eat me" (anti-phagocytic) signal.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Peptide
International Nonproprietary Names Click here for help
INN number INN
12029 evorpacept
Synonyms Click here for help
ALX-148 | ALX148
Database Links Click here for help
GtoPdb PubChem SID 442878626
Search PubMed clinical trials evorpacept
Search PubMed titles evorpacept
Search PubMed titles/abstracts evorpacept