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loncastuximab tesirine   Click here for help

GtoPdb Ligand ID: 11521

Synonyms: ADCT-402 | ADCT402 | loncastuximab tesirine-lpyl | RB4v1.2-SG-3249 | Zynlonta®
Approved drug
loncastuximab tesirine is an approved drug (FDA (2021), EMA (2022))
Compound class: Antibody
Comment: Loncastuximab tesirine (ADCT-402) is an antibody-drug conjugate that delivers the toxic payload teserine (pyrrolobenzodiazepine dimer SG3249, which acts as a DNA alkylating and cross-linking agent [3]) to CD19-expressing B cells [4].
Classification Click here for help
Compound class Antibody
Approved drug? Yes. China NMPA (2024)  |  EU EMA (2022)  |  US FDA (2021)
International Nonproprietary Names Click here for help
INN number INN
10586 loncastuximab tesirine
Synonyms Click here for help
ADCT-402 | ADCT402 | loncastuximab tesirine-lpyl | RB4v1.2-SG-3249 | Zynlonta®
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 749
Other databases
GtoPdb PubChem SID 441604893
Search PubMed clinical trials loncastuximab tesirine
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